OL-033 Etambutol-mediated changes in rat liver cytochrome P-450 isoforms expression and DNA-fragmentation processes
نویسندگان
چکیده
منابع مشابه
Studies on the synthesis of cytochrome P-450 and cytochrome P-448 in rat liver.
The synthesis of cytochrome P-450 (phenobarbital inducible) and cytochrome P-448 (3-methylcholanthrene inducible) have been studied in rat liver in vivo and in the wheat germ cell-free system using anti-cytochrome P-450 and anti-cytochrome P-448 antibodies. The major mature forms synthesized in vivo correspond to a molecular weight of 47,000 for cytochrome P-450 and 53,000 for cytochrome P-448....
متن کاملIdentification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes.
The metabolism of cis-tramadol has been studied in human liver microsomes and in cDNA-expressed human cytochrome P-450 (CYP) isoforms. Human liver microsomes catalyzed the NADPH-dependent metabolism of tramadol to the two primary tramadol metabolites, namely, O-desmethyl-tramadol (metabolite M1) and N-desmethyl-tramadol (metabolite M2). In addition, tramadol was also metabolized to two minor se...
متن کاملEvidence That lsoniazid and Ethanol Induce the Same Microsomal Cytochrome P-450 in Rat Liver, an lsozyme Homologous to Rabbit Liver Cytochrome P-450 lsozyme 3a
Cytochrome P-45Oj has been purified to electrophoretic. homogeneity from hepatic microsomes of adult male rats administered ethanol and compared to the corresponding enzyme from isoniazid-treated rats. The enzymes isolated from ethanoland isoniazidtreated rats have identical chromatographic properties, minimum molecular weights, spectral properties, peptide maps, NHz-terminal sequences, immunoc...
متن کاملAsymmetric distribution of cytochrome P-450 and NADPH--cytochrome P-450 (cytochrome c) reductase in vesicles from smooth endoplasmic reticulum of rat liver.
1. The topography of cytochrome P-450 in vesicles from smooth endoplasmic reticulum of rat liver has been examined. Approx. 50% of the cytochrome is directly accessible to the action of trypsin in intact vesicles whereas the remainder is inaccessible and partitioned between luminal-facing or phospholipid-embedded loci. Analysis by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis revea...
متن کاملInteraction of liver microsomal cytochrome P-450 and NADPH-cytochrome P-450 reductase in the presence and absence of lipid.
Phospholipid has been reported to be necessary for optimal catalytic activity of a number of mammalian cytochrome P-450 (P-450) systems. We also confirm that a number of individual phospholipids and mixtures, used as soluble monomers or phospholipid vesicles, show activation of 7-ethoxycoumarin O-deethylase activity by an enzyme system composed of rat liver microsomal P-450PB-B and NADPH-P-450 ...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2011
ISSN: 1201-9712
DOI: 10.1016/s1201-9712(11)60093-3